{"product_id":"arkadia-polyclonal-antibody-bt-ap00614","title":"Arkadia Polyclonal Antibody - BT-AP00614","description":"\u003cp\u003eArkadia Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP00614-20, BT-AP00614-50, BT-AP00614-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by RNF111 (ring finger protein 111) is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF)-beta\/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, RNF111 plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of RNF111 results in multiple transcript variants encoding distinct isoforms.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Others\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: RNF111\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Arkadia Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 108876\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q6ZNA4; Mouse: Q99ML9\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: RNF111; E3 ubiquitin-protein ligase Arkadia; RING finger protein 111\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 54778; Mouse: 93836\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240120115379,"sku":"BT-AP00614-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240120148147,"sku":"BT-AP00614-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240120180915,"sku":"BT-AP00614-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_1232e9c6-c884-4d18-8398-858acf7e5c5f.png?v=1769403716","url":"https:\/\/afsbio.com\/products\/arkadia-polyclonal-antibody-bt-ap00614","provider":"AFSBio Inc.","version":"1.0","type":"link"}