{"product_id":"arrb1-monoclonal-antibody-bt-mca2250","title":"ARRB1 Monoclonal Antibody - BT-MCA2250","description":"\u003cp\u003eARRB1 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2250-50, BT-MCA2250-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Members of arrestin\/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK\/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: ARRB1\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 4E11B1\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: ARRB1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human ARRB1 (AA: 89-268) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 47kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P49407\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: ARB1, ARR1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 408\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238423781555,"sku":"BT-MCA2250-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238423814323,"sku":"BT-MCA2250-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_600039cc-b162-4bc5-8ae5-4870287e5b8d.png?v=1769380552","url":"https:\/\/afsbio.com\/products\/arrb1-monoclonal-antibody-bt-mca2250","provider":"AFSBio Inc.","version":"1.0","type":"link"}