{"product_id":"arrestin-beta-2-monoclonal-antibody-bt-mca0186","title":"Arrestin-Beta-2 Monoclonal Antibody - BT-MCA0186","description":"\u003cp\u003eArrestin-Beta-2 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA0186-50, BT-MCA0186-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Members of arrestin\/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: ARRB2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IF, ICC\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human,Mouse,Rat,Pig\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Beta-arrestin-2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P32121; Mouse: Q91YI4; Rat: P29067\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: ARRB2; ARB2; ARR2; Beta-arrestin-2; Arrestin beta-2\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 409; Mouse: 216869; Rat: 25388\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238665019571,"sku":"BT-MCA0186-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238665052339,"sku":"BT-MCA0186-100","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_36906bdf-8dbc-4540-ae42-8576ac953ccb.png?v=1769383570","url":"https:\/\/afsbio.com\/products\/arrestin-beta-2-monoclonal-antibody-bt-mca0186","provider":"AFSBio Inc.","version":"1.0","type":"link"}