{"product_id":"as160-phospho-ser318-rabbit-polyclonal-antibody-bt-ap06039","title":"AS160 (Phospho-Ser318) Rabbit Polyclonal Antibody - BT-AP06039","description":"\u003cp\u003eAS160 (Phospho-Ser318) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP06039-20, BT-AP06039-50, BT-AP06039-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene is a member of the Tre-2\/BUB2\/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein| and contains two phopshotyrosine-binding domains (PTB1 and PTB2)| a calmodulin-binding domain (CBD)| a Rab-GTPase domain| and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4)| important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane| suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin| this protein is phosphorylated| dissociates from GLUT4 vesicles| resulting in increased GLUT4 at the cell surface| and enhanced glucose transport. Ph\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: TBC1D4\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: AS160\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: O60343; Mouse: Q8BYJ6\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: AS160;Ser318; TBC1 domain family member 4; Akt substrate of 160 kDa; AS160\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 9882; Mouse: 210789\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45238966091955,"sku":"BT-AP06039-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45238966124723,"sku":"BT-AP06039-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238966157491,"sku":"BT-AP06039-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_b5c9056f-a11e-4250-ae3b-5f0db3d42ccc.png?v=1769387344","url":"https:\/\/afsbio.com\/products\/as160-phospho-ser318-rabbit-polyclonal-antibody-bt-ap06039","provider":"AFSBio Inc.","version":"1.0","type":"link"}