{"product_id":"ataxin-1-polyclonal-antibody-bs7968","title":"Ataxin-1 Polyclonal Antibody-BS7968","description":"\u003cp\u003eAtaxin-1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS7968-50, BS7968-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P54253\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB IF\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1:500~1:2000\u003cbr\u003e\nIF: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: Ataxin-1, also designated spinocerebellar ataxia type 1 protein (Sca-1), is differentially expressed and localizes to both the cytoplasm and the nucleus. Mutations in Ataxin-1 are associated with the onset of the autosomal dominant neurodegenerative disorder spinocerebellar ataxia type 1 (SCA-1), which is characterized by progressive neuronal loss in the cerebellum, muscle wasting and ataxia. In Purkinje cells, where SCA-1 is predominantly observed, Ataxin-1 has been shown to directly associate with the Purkinje-enriched leucine-rich acidic nuclear protein (LANP) and the nuclear matrix-associated protein promyelocytic leukemia protein PML. In SCA-1, Ataxin-1 is mutated to encode a polyglutamine protein that forms nuclear aggregates, which interact significantly more strongly with LANP and contribute to the pathogenesis of SCA-1.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Ataxin-1 polyclonal antibody detects endogenous levels of Ataxin-1 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 84 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western Blot (WB) analysis of Ataxin-1 polyclonal antibody\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: alternative ataxin1; \u003cbr\u003e\nAtaxin-1; \u003cbr\u003e\nATX1; \u003cbr\u003e\nATX1_HUMAN; \u003cbr\u003e\nAtxn1; \u003cbr\u003e\nD6S504E; \u003cbr\u003e\nSCA1; \u003cbr\u003e\nSpinocerebellar ataxia type 1 protein;\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Recombinant full length Human Ataxin-1.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42923512430771,"sku":"BS7968-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42923512463539,"sku":"BS7968-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_84d3b013-f3c1-4ece-8ee6-1d5484fd5daf.jpg?v=1703850829","url":"https:\/\/afsbio.com\/products\/ataxin-1-polyclonal-antibody-bs7968","provider":"AFSBio Inc.","version":"1.0","type":"link"}