{"product_id":"atf-2-phospho-thr69-71-rabbit-polyclonal-antibody-bt-ap06163","title":"ATF-2 (Phospho-Thr69\/71) Rabbit Polyclonal Antibody - BT-AP06163","description":"\u003cp\u003eATF-2 (Phospho-Thr69\/71) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP06163-20, BT-AP06163-50, BT-AP06163-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE)| an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cellandapos;s DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Epigenetics and nuclear signaling; Immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: ATF2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: ATF-2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P15336; Mouse: P16951; Rat: Q00969\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: ATF-2;Thr69\/71; Cyclic AMP-dependent transcription factor ATF-2; cAMP-dependent transcription factor ATF-2; Activating transcription factor 2; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding protein 2; HB16; cAMP response element-binding protein CRE-BP1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 1386; Mouse: 100047997; Rat: 81647\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45238967337139,"sku":"BT-AP06163-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45238967369907,"sku":"BT-AP06163-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238967402675,"sku":"BT-AP06163-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_0ede9314-f51d-44c6-b1d5-217d2e36f17d.png?v=1769387355","url":"https:\/\/afsbio.com\/products\/atf-2-phospho-thr69-71-rabbit-polyclonal-antibody-bt-ap06163","provider":"AFSBio Inc.","version":"1.0","type":"link"}