{"product_id":"atf3-rabbit-monoclonal-antibody-mb66422","title":"ATF3 Rabbit Monoclonal Antibody-MB66422","description":"\u003cp\u003eATF3 Rabbit Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB66422-50, MB66422-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P18847\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IP\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB (1\/500 - 1\/1000), IP (1\/10 - 1\/50)\u003c\/p\u003e\n\n\u003cp\u003eBackground: Activating transcription factor 3 (ATF-3) is a basic leucine zipper-type transcription factor belonging to the ATF\/cAMP responsive element binding protein family. ATF-3 can form homodimers or heterodimers with other family members and depending on the cell types and promoter context, it can suppress or activate the transcription of its target genes. Expression of ATF-3 is induced by a variety of factors including cytokines, genotoxic agents, and physiological stress. For example, both metformin and high-density lipoprotein (HDL) can induce ATF-3 expression in macrophages. Research studies also indicate that ATF-3 can function as an oncogene or a tumor suppressor depending on the context .\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was purified by immunogen affinity chromatography.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of ATF3 protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of ATF3 expression in MCF7 (A), U251 (B), HL60 (C) whole cell lysates.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 23 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Cyclic AMP-dependent transcription factor ATF-3; cAMP-dependent transcription factor ATF-3; Activating transcription factor 3\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein of human ATF3\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42906361004211,"sku":"MB66422-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42906361036979,"sku":"MB66422-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_d714f43c-88e8-4ce6-aef3-e82922eb188b.jpg?v=1702918667","url":"https:\/\/afsbio.com\/products\/atf3-rabbit-monoclonal-antibody-mb66422","provider":"AFSBio Inc.","version":"1.0","type":"link"}