{"product_id":"atm-mouse-monoclonal-antibody-3d3-bt-mca0194","title":"ATM mouse Monoclonal Antibody (3D3) - BT-MCA0194","description":"\u003cp\u003eATM mouse Monoclonal Antibody (3D3)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-MCA0194-20, BT-MCA0194-50, BT-MCA0194-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene belongs to the PI3\/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates| thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and nuclear signaling; Cancer\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: ATM\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC-p, IF\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human,Rat,Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: ATM\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q13315; Mouse: Q62388\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: ATM\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 472\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240031871155,"sku":"BT-MCA0194-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240031903923,"sku":"BT-MCA0194-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240031936691,"sku":"BT-MCA0194-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_cd25c4c8-7df7-42ef-954c-e0c5af1c40b9.png?v=1769402416","url":"https:\/\/afsbio.com\/products\/atm-mouse-monoclonal-antibody-3d3-bt-mca0194","provider":"AFSBio Inc.","version":"1.0","type":"link"}