{"product_id":"atm-rabbit-monoclonal-antibody-bs9893m","title":"ATM Rabbit Monoclonal Antibody-BS9893M","description":"\u003cp\u003eATM Rabbit Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS9893M-50, BS9893M-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q13315\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ICC\/IF, IHC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1:1000-1:5000 \u003cbr\u003e\nICC\/IF: 1:50-1:200\u003cbr\u003e\nIHC: 1:50-1:200\u003c\/p\u003e \n\n\u003cp\u003eBackground: The phosphatidylinositol kinase (PIK) family members fall into two distinct subgroups. The first subgroup contains proteins such as the PI 3- and PI 4-kinases and the second group comprises the PIK-related kinases. The PIK-related kinases include Atm, DNA-PKCS and FRAP. These proteins have in common a region of homology at their carboxy-termini that is not present in the PI 3- and PI 4-kinases. The Atm gene is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) that is characterized by cerebellar degeneration (ataxia) and the appearance of dilated blood vessels (telangiec-tases) in the conjunctivae of the eyes. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Protein A affinity purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of ATM and does not cross-react with related proteins.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 370 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of ATM Rabbit mAb at 1:1000 dilution\u003cbr\u003e\n Lane 1: CRC whole cell lysate, Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-ATM antibody. Counter stained with hematoxylin., ICC staining ATM in Hela cells (green). The nuclear counter stain is DAPI (blue).Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton *100\/PBS.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated; ATM\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant antibody.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":43044032086195,"sku":"BS9893M-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":43044032118963,"sku":"BS9893M-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_2ab7e5ba-0973-4ca9-8be9-d21ee741387c.jpg?v=1707738759","url":"https:\/\/afsbio.com\/products\/atm-rabbit-monoclonal-antibody-bs9893m","provider":"AFSBio Inc.","version":"1.0","type":"link"}