{"product_id":"atm-rabbit-rabbit-pab-es20823","title":"ATM Rabbit rabbit pAb - ES20823","description":"\u003cp\u003eATM Rabbit rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES20823-50, ES20823-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene belongs to the PI3\/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: ATM\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC; IF\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:100-200\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Rat; Mouse\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant Protein of ATM of ATM\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 350kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 472\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q13315\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus. Cytoplasmic vesicle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Primarily nuclear. Found also in endocytic vesicles in association with beta-adaptin.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202437439667,"sku":"ES20823-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202437472435,"sku":"ES20823-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_9df6420c-3810-4371-98af-48f85367645e.png?v=1767129149","url":"https:\/\/afsbio.com\/products\/atm-rabbit-rabbit-pab-es20823","provider":"AFSBio Inc.","version":"1.0","type":"link"}