{"product_id":"atp4a-rabbit-polyclonal-antibody-es10038","title":"ATP4A Rabbit Polyclonal Antibody - ES10038","description":"\u003cp\u003eATP4A Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES10038-50, ES10038-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: approximately 7-10 business days, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes a catalytic alpha subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008],\u003c\/p\u003e \n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human protein . at AA range: 800-880\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: ATP4A,\u003c\/p\u003e \n\n\u003cp\u003eSpecificity: ATP4A Polyclonal Antibody detects endogenous levels of protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000 ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e \n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Expressed in gastric parietal cells (at protein level).\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 113kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Oxidative phosphorylation, Metabolic pathways, Collecting duct acid secretion, Gastric acid secretion\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: ATP + H(2)O + H(+)(In) + K(+)(Out) = ADP + phosphate + H(+)(Out) + K(+)(In). Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach. Similarity: Belongs to the cation transport ATPase (P-type) family. Similarity: Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily. Subunit: Composed of two subunits: alpha (catalytic) and beta. Tissue Specificity: Found in gastric mucosa.\u003c\/p\u003e \n\n\u003cp\u003eSubcellular Location: Apical cell membrane, Multi-pass membrane protein Localized in the apical canalicular membrane of parietal cells (PubMed:24188822). Localized in the apical canalicular membrane of parietal cells (PubMed:24188822).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: ATP4A\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Potassium-transporting ATPase alpha chain 1, EC 3.6.3.10, Gastric H(+ \/K(+ ATPase subunit alpha, Proton pump\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 495\u003c\/p\u003e\n\n\u003cp\u003eHuman SwissProt Number: P20648\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q64436\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: P09626\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":45825499136179,"sku":"ES10038-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45825499168947,"sku":"ES10038-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk-biotechnology-logo-product.jpg?v=1786476023","url":"https:\/\/afsbio.com\/products\/atp4a-rabbit-polyclonal-antibody-es10038","provider":"AFSBio Inc.","version":"1.0","type":"link"}