{"product_id":"avr2b-polyclonal-antibody-bt-ap06615","title":"AVR2B Polyclonal Antibody - BT-AP06615","description":"\u003cp\u003eAVR2B Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP06615-20, BT-AP06615-50, BT-AP06615-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine\/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. Th\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal transduction; Stem cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: ACVR2B\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Activin receptor type-2B\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q13705; Mouse: P27040; Rat: P38445\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Activin receptor type-2B;EC 2.7.11.30;Activin receptor type IIB;ACTR-IIB\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 93\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239061807283,"sku":"BT-AP06615-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239061840051,"sku":"BT-AP06615-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239061872819,"sku":"BT-AP06615-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_69c172a1-67d0-4f78-b6fb-afc1eca025a1.png?v=1769388589","url":"https:\/\/afsbio.com\/products\/avr2b-polyclonal-antibody-bt-ap06615","provider":"AFSBio Inc.","version":"1.0","type":"link"}