{"product_id":"axin1-polyclonal-antibody-bt-ap06619","title":"AXIN1 Polyclonal Antibody - BT-AP06619","description":"\u003cp\u003eAXIN1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP06619-20, BT-AP06619-50, BT-AP06619-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cell biology; Signal transduction; Stem cells; Tags and cell markers\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: AXIN1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Axin-1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: O15169; Mouse: O35625; Rat: O70239\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Axin-1;Axis inhibition protein 1;hAxin\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 8312\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239062003891,"sku":"BT-AP06619-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239062036659,"sku":"BT-AP06619-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239062069427,"sku":"BT-AP06619-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_26e3e886-27db-4440-90a9-f8077af4f6fd.png?v=1769388593","url":"https:\/\/afsbio.com\/products\/axin1-polyclonal-antibody-bt-ap06619","provider":"AFSBio Inc.","version":"1.0","type":"link"}