{"product_id":"b4gt7-rabbit-polyclonal-antibody-es9450","title":"B4GT7 Rabbit Polyclonal Antibody - ES9450","description":"\u003cp\u003eB4GT7 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES9450-50, ES9450-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene is a member of the beta-1,4-galactosyltransferase (beta4GalT) family. Family members encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose. Each beta4GalT member has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus which then remains uncleaved to function as a transmembrane anchor. The enzyme encoded by this gene attaches the first galactose in the common carbohydrate-protein linkage (GlcA-beta1,3-Gal-beta1,3-Gal-beta1,4-Xyl-beta1-O-Ser) found in proteoglycans. This enzyme differs from other beta4GalTs because it lacks the conserved Cys residues found in beta4GalT1-beta4GalT6 and it is located in cis-Golgi instead of trans-Golgi. M\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from part region of human protein\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: B4GT7\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: B4GT7 Polyclonal Antibody detects endogenous levels of protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000 ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: High expression in heart, pancreas and liver, medium in placenta and kidney, low in brain, skeletal muscle and lung,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 35kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Glycosaminoglycan biosynthesis - chondroitin sulfate \/ dermatan sulfate, Glycosaminoglycan biosynthesis - heparan sulfate \/ heparin, Metabolic pathways\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: UDP-galactose + O-beta-D-xylosylprotein = UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein\u003cbr\u003e\nCofactor: Manganese\u003cbr\u003e\nDisease: Defects in B4GALT7 are the cause of progeroid Ehlers-Danlos syndrome (EDS) [MIM: 130070]. EDSP is a variant form of Ehlers-Danlos syndrome characterized by progeroid facies, mild mental retardation, short stature, skin hyperextensibility, moderate skin fragility, joint hypermobility principally in digits\u003cbr\u003e\nFunction: Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts\u003cbr\u003e\nOnline Information: Beta-1,4-galactosyltransferase 7,Online Information: GlycoGene database,Pathway: Protein modification, protein glycosylation\u003cbr\u003e\nSimilarity: Belongs to the glycosyltransferase 7 family\u003cbr\u003e\nSubcellular Location: Cis cisternae of Golgi stack\u003cbr\u003e\nTissue Specificity: High expression in heart, pancreas\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Golgi apparatus, Golgi stack membrane, Single-pass type II membrane protein Cis cisternae of Golgi stack\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: B4GALT7 XGALT1 UNQ748\/PRO1478\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Beta-1,4-galactosyltransferase 7 (Beta-1,4-GalTase 7) (Beta4Gal-T7) (b4Gal-T7) (EC 2.4.1.-) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-gala\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q8R087\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46314131816627,"sku":"ES9450-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46314131849395,"sku":"ES9450-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/b4gt7-rabbit-polyclonal-antibody-es9450","provider":"AFSBio Inc.","version":"1.0","type":"link"}