{"product_id":"bage5-rabbit-polyclonal-antibody-es3791","title":"BAGE5 Rabbit Polyclonal Antibody - ES3791","description":"\u003cp\u003eBAGE5 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES3791-50, ES3791-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70\/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: BAG5, KIAA0873, BAG family molecular chaperone regulator 5, BAG-5, Bcl-2-associated athanogene 5\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from BAGE5. at AA range: 30-110\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: BAGE5\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: BAGE5 Polyclonal Antibody detects endogenous levels of BAGE5 protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/5000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Brain,\u003c\/p\u003e \n\n\u003cp\u003eObserved Band (KD): 51kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: Inhibits the chaperone activity of HSP70\/HSC70 by promoting substrate release. Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2\u003cbr\u003e\nSimilarity: Contains 4 BAG domains\u003cbr\u003e\nSubunit: Binds to the ATPase domain of HSP70\/HSC chaperones. Binds PARK2\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: nucleus, mitochondrion, cytosol, membrane, inclusion body, perinuclear region of cytoplasm,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: BAG5\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: BAG family molecular chaperone regulator 5\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 70369\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q8CI32\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 366734\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: Q5QJC9\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46316505923763,"sku":"ES3791-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46316505956531,"sku":"ES3791-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/bage5-rabbit-polyclonal-antibody-es3791","provider":"AFSBio Inc.","version":"1.0","type":"link"}