{"product_id":"bap1-phospho-ser592-rabbit-polyclonal-antibody-bt-ap06274","title":"BAP1 (Phospho-Ser592) Rabbit Polyclonal Antibody - BT-AP06274","description":"\u003cp\u003eBAP1 (Phospho-Ser592) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP06274-20, BT-AP06274-50, BT-AP06274-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition| the enzyme may be involved in regulation of transcription| regulation of cell cycle and growth| response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS)| which involves increased risk of cancers including malignant mesothelioma| uveal melanoma and cutaneous melanoma.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cancer; Cell biology; Epigenetics and nuclear signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: BAP1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: BAP1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q92560; Mouse: Q99PU7; Rat: D3ZHS6\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: BAP1;Ser592; Ubiquitin carboxyl-terminal hydrolase BAP1; EC 3.4.19.12; BRCA1-associated protein 1; Cerebral protein 6\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 8314; Mouse: 104416; Rat: 306257\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45238970220723,"sku":"BT-AP06274-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45238970253491,"sku":"BT-AP06274-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238970286259,"sku":"BT-AP06274-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_fd20f855-0f8e-4e20-b9cb-92285565e79d.png?v=1769387378","url":"https:\/\/afsbio.com\/products\/bap1-phospho-ser592-rabbit-polyclonal-antibody-bt-ap06274","provider":"AFSBio Inc.","version":"1.0","type":"link"}