{"product_id":"bax-2b12-monoclonal-antibody-mb3042","title":"Bax (2B12) Monoclonal Antibody-MB3042","description":"\u003cp\u003eBax (2B12) Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB3042-50, MB3042-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q07812\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human,Monkey\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1\/500-1\/1000\u003c\/p\u003e  \n\n\u003cp\u003eBackground: Bax is a key component for cellular induced apoptosis through mitochondrial stress. Upon apoptotic stimulation, Bax forms oligomers and translocates from the cytosol to the mitochondrial membrane. Through interactions with pore proteins on the mitochondrial membrane, Bax increases the membrane's permeability, which leads to the release of cytochrome c from mitochondria, activation of caspase-9 and initiation of the caspase activation pathway for apoptosis.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Affinity Purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of Bax in COS7, Raji, CEM and HelaLysates using Bax antibody.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: Calculated MW: 21 kDa; Observed MW: 21 kDa\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: IgG2a\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Apoptosis regulator BAX; BAX; Bcl-2-like protein 4; BCL2-associated X protein; Bcl2-L-4; BCL2L4\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant human Bax protein fragments expressed in E.coli\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42932524286131,"sku":"MB3042-50","price":415.38,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42932524318899,"sku":"MB3042-100","price":640.78,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_ce900092-a5b3-492b-aed2-633987a78697.jpg?v=1704284481","url":"https:\/\/afsbio.com\/products\/bax-2b12-monoclonal-antibody-mb3042","provider":"AFSBio Inc.","version":"1.0","type":"link"}