{"product_id":"bbc3-polyclonal-antibody-e-ab-40332","title":"BBC3 Polyclonal Antibody - E-AB-40332","description":"\u003cp\u003eBBC3 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-40332-60, E-AB-40332-120, E-AB-40332-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: BBC3\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: BBC 3; Bbc3; BBC3; BCL 2 binding component 3; Bcl-2-binding component 3; BCL2 binding component 3; JFY 1; JFY-1; JFY1; p53 up regulated modulator of apoptosis; p53 up-regulated modulator of apoptosis; p53 Upregulated Modulator of Apoptosis; PUMA alpha; PUMA\/JFY1\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Cell Biology, Metabolism, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q9BXH1\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 4.3mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant Human Bcl-2-binding component 3 protein\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB:1:500-1000 IHC 1:100-1:200\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 21kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 26kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146027434163,"sku":"E-AB-40332-60","price":175.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146027466931,"sku":"E-AB-40332-120","price":322.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146027499699,"sku":"E-AB-40332-200","price":532.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_84490137-840f-4bf6-9667-528e4d831f30.png?v=1710290084","url":"https:\/\/afsbio.com\/products\/bbc3-polyclonal-antibody-e-ab-40332","provider":"AFSBio Inc.","version":"1.0","type":"link"}