{"product_id":"bcl-10-polyclonal-antibody-bt-ap00856","title":"Bcl-10 Polyclonal Antibody - BT-AP00856","description":"\u003cp\u003eBcl-10 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP00856-20, BT-AP00856-50, BT-AP00856-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: BCL10 (B-cell CLL\/lymphoma 10) was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by BCL10 contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: BCL10\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Bcl-10 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 26252\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: O95999; Mouse: Q9Z0H7; Rat: Q9QYN5\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: BCL10; CIPER; CLAP; B-cell lymphoma\/leukemia 10; B-cell CLL\/lymphoma 10; Bcl-10; CARD-containing molecule enhancing NF-kappa-B; CARD-like apoptotic protein; hCLAP; CED-3\/ICH-1 prodomain homologous E10\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 8915; Mouse: 12042; Rat: 83477\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240135450803,"sku":"BT-AP00856-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240135483571,"sku":"BT-AP00856-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240135516339,"sku":"BT-AP00856-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_92683457-c559-4c87-9ff1-eec191230a0d.png?v=1769403983","url":"https:\/\/afsbio.com\/products\/bcl-10-polyclonal-antibody-bt-ap00856","provider":"AFSBio Inc.","version":"1.0","type":"link"}