{"product_id":"bcl-2-mouse-mab-em1041","title":"Bcl-2 Mouse mAb - EM1041","description":"\u003cp\u003eBcl-2 Mouse mAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: EM1041-50, EM1041-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: BCL2 is an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. BCL2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. It regulates cell death by controlling the mitochondrial membrane permeability.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Name: B-Cell Leukemia\/Lymphoma 2 ; B-Cell CLL\/Lymphoma 2\u003c\/p\u003e\n\n\u003cp\u003eSource: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:1, 000-2, 000 IHC 1:200 IF 1:100-200\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic Peptide\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG1\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 26kDa\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 596\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P10415\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Mitochondrion outer membrane, Nucleus membrane, Endoplasmic reticulum membrane\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45201986191539,"sku":"EM1041-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45201986224307,"sku":"EM1041-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_2555011a-029f-4028-904f-3c1e9d57d87f.png?v=1767119383","url":"https:\/\/afsbio.com\/products\/bcl-2-mouse-mab-em1041","provider":"AFSBio Inc.","version":"1.0","type":"link"}