{"product_id":"bcl-2-polyclonal-antibody-bs65629","title":"Bcl-2 Polyclonal Antibody-BS65629","description":"\u003cp\u003eBcl-2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS65629-50, BS65629-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P49950\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat,\u003c\/p\u003e \n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB=1:500-2000\u003c\/p\u003e \n\n\u003cp\u003eBackground: The Bcl-2 gene was isolated at the chromosomal breakpoint of t(14;18)-bearing follicular B cell lymphomas(1,2).Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal (3,5).Bcl-2 appears to function in several subcellular locations yet lacks any known motifs that would confer insight into its mechanism of action (6,7).A more recently identified protein,designated Bax p21(i.e., Bcl-associated X protein ),has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2(8). Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line and Bax also counters the death repressor activty of Bcl-2(8).\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: affinity purified by Protein A\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Bcl-2 Polyclonal Antibody detects endogenous levels of Bcl-2 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 26 kD\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Sample:\u003cbr\u003e\n Lane 1: Spleen (Mouse) Lysate at 40 ug\u003cbr\u003e\n Lane 2: Lymph node (Mouse) Lysate at 40 ug\u003cbr\u003e\n Lane 3: Lymph node (Rat) Lysate at 40 ug\u003cbr\u003e\n Lane 4: MCF-7 (Human) Cell Lysate at 30 ug\u003cbr\u003e\n Lane 5: SiHa (Human) Cell Lysate at 30 ug\u003cbr\u003e\n Lane 6: Jurkat (Human) Cell Lysate at 30 ug\u003cbr\u003e\n Lane 7: A431 (Human) Cell Lysate at 30 ug\u003cbr\u003e\n Lane 8: Bone (Rat) Lysate at 40 ug\u003cbr\u003e\n Lane 9: Bone (Mouse) Lysate at 40 ug\u003cbr\u003e\n Lane 10: A549 (Human) Cell Lysate at 30 ug\u003cbr\u003e\n Lane 11: SH-SY5Y (Human) Cell Lysate at 30 ug\u003cbr\u003e\n Primary: Anti-Bcl-2 at 1\/1000 dilution\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Apoptosis regulator Bcl 2; Apoptosis regulator Bcl2; AW986256; B cell CLL\/lymphoma 2; B cell leukemia\/lymphoma 2; B cell lymphoma 2; Bcl 2; Bcl-2; Bcl2; BCL2 protein; C430015F12Rik; D630044D05Rik; D830018M01Rik; Leukemia\/lymphoma, B-cell, 2; Oncogene B-cell leukemia 2; BCL2_HUMAN.\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: KLH conjugated synthetic peptide derived from human Bcl-2\u003c\/p\u003e \n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":43029544960179,"sku":"BS65629-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":43029544992947,"sku":"BS65629-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_a8534a2e-518c-4feb-b6bf-a7bf8ebb5e74.jpg?v=1707221475","url":"https:\/\/afsbio.com\/products\/bcl-2-polyclonal-antibody-bs65629","provider":"AFSBio Inc.","version":"1.0","type":"link"}