{"product_id":"bcl-w-rabbit-pab-es1760","title":"Bcl-w rabbit pAb - ES1760","description":"\u003cp\u003eBcl-w rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES1760-50, ES1760-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly (A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: BCL2L2; BCLW; KIAA0271; Bcl-2-like protein 2; Bcl2-L-2; Apoptosis regulator Bcl-W\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/10000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human BCLW. AA range:131-180\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 25kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 599\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q92843\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Mitochondrion membrane; Peripheral membrane protein. Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202035278003,"sku":"ES1760-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202035310771,"sku":"ES1760-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_eabc904e-22d8-4ff2-8bf0-a9fe05cf0ad2.png?v=1767120365","url":"https:\/\/afsbio.com\/products\/bcl-w-rabbit-pab-es1760","provider":"AFSBio Inc.","version":"1.0","type":"link"}