{"product_id":"bcl10-monoclonal-antibody-bt-mca3408","title":"BCL10 Monoclonal Antibody - BT-MCA3408","description":"\u003cp\u003eBCL10 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA3408-50, BT-MCA3408-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: BCL10\u003c\/p\u003e\n\n\u003cp\u003eApplications: FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 3C11F4\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: BCL10\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human BCL10 (AA: 98-234) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 26.3kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: O95999\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: CLAP, mE10, CIPER, IMD37, c-E10, CARMEN\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 8915\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238527099059,"sku":"BT-MCA3408-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238527131827,"sku":"BT-MCA3408-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_bbb77ef2-991b-40fc-9202-d4673df181c3.png?v=1769382252","url":"https:\/\/afsbio.com\/products\/bcl10-monoclonal-antibody-bt-mca3408","provider":"AFSBio Inc.","version":"1.0","type":"link"}