{"product_id":"bcl10-monoclonal-antibody-mb66748","title":"BCL10 Monoclonal Antibody - MB66748","description":"\u003cp\u003eBCL10 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB66748-50, MB66748-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Bcl10, also designated CIPER, c-CARMEN and mE10, was first identified as a gene truncated or mutated in MALT B cell lymphomas and other tumor types.Bcl10 is homologous to the equine herpes virus-2 E10 gene, and like E10 it contains an amino-terminal caspase recruitment domain (CARD). Expression of Bcl10 was shown to induce NFκB activation in a NIK-dependent pathway, and the CARD domain was shown to be essential for this activation. In a separate study, Bcl10 by itself did not induce JNK or NFκB activation. Overexpression of Bcl10 was shown to induce apoptosis, in a manner that was dependent on CARD-mediated oligomerization. Bcl10 was also shown to play a role in processing of caspase-9 to its active dimer. Other studies have shown that Bcl10 is not mutated in many human tumors and lymphomas.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, FC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CIPER, CLAP, B-cell lymphoma\/leukemia 10, B-cell CLL\/lymphoma 10, Bcl-10, CARD-containing molecμle enhancing NF-kappa-B, CARD-like apoptotic protein, hCLAP, CED-3\/ICH-1 prodomain homologous E10-like regμlator, CIPER, Cellμlar homolog of vCARMEN, cCARMEN, Cellμlar-E10, c-E10, Mammalian CARD-containing adapter molecμle E10, mE10\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human BCL10. The exact sequence is proprietary.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB (1\/500 - 1\/1000), IHC (1\/50 - 1\/200), FC (1\/10 - 1\/50)\u003c\/p\u003e\n\n\u003cp\u003ePurification: This antibody is purified through a protein G column.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of BCL10 protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 28 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: T cell receptor signaling\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: O95999\u003c\/p\u003e\n\n\u003cp\u003eProduct: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946418987187,"sku":"MB66748-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946419019955,"sku":"MB66748-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/bcl10-monoclonal-antibody-mb66748","provider":"AFSBio Inc.","version":"1.0","type":"link"}