{"product_id":"bcl2l1-polyclonal-antibody-e-ab-60013","title":"BCL2L1 Polyclonal Antibody - E-AB-60013","description":"\u003cp\u003eBCL2L1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-60013-60, E-AB-60013-120, E-AB-60013-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: BCL2L1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: BCL2L1; BCL-XL\/S; BCL2L; BCLX; Bcl-X; PPP1R52; BCL2 like 1; Bcl-XL\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Cell Biology, Metabolism, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC, IF\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q07817\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human BCL2L1 (NP_612815.1).\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC \t1:50-1:200   IF \t1:50-1:200\u003c\/p\u003e\n\n \n\n \n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43133590143155,"sku":"E-AB-60013-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43133590175923,"sku":"E-AB-60013-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43133590208691,"sku":"E-AB-60013-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_767e98f6-e327-494d-b408-d36f8eccac67.png?v=1709900567","url":"https:\/\/afsbio.com\/products\/bcl2l1-polyclonal-antibody-e-ab-60013","provider":"AFSBio Inc.","version":"1.0","type":"link"}