{"product_id":"best1-polyclonal-antibody-e-ab-65423","title":"BEST1 Polyclonal Antibody - E-AB-65423","description":"\u003cp\u003eBEST1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-65423-60, E-AB-65423-120, E-AB-65423-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: BEST1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: BEST1; ARB; BEST; BMD; RP50; TU15B; VMD2\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer,Neuroscience\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: O76090\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthetic peptide of human BEST1\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 57kDa\/67kDa\/69kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 70kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146369466547,"sku":"E-AB-65423-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146369499315,"sku":"E-AB-65423-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146369532083,"sku":"E-AB-65423-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_1af5fff1-1c8e-4dcc-84b3-a67df849aafc.png?v=1710294406","url":"https:\/\/afsbio.com\/products\/best1-polyclonal-antibody-e-ab-65423","provider":"AFSBio Inc.","version":"1.0","type":"link"}