{"product_id":"bestrophin-1-rabbit-pab-es20817","title":"Bestrophin-1 rabbit pAb - ES20817","description":"\u003cp\u003eBestrophin-1 rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES20817-50, ES20817-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Nov 2008],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: Bestrophin-1 (TU15B; Vitelliform macular dystrophy protein 2)\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC; IF\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/40000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Rat; Mouse\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic Peptide of Bestrophin-1 AA range: 161-211\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 67kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 7439\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: O76090\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cell membrane; Multi-pass membrane protein. Basolateral cell membrane.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202437308595,"sku":"ES20817-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202437341363,"sku":"ES20817-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_1e9f41fa-36f6-4af9-89c1-a6818412bba9.png?v=1767129146","url":"https:\/\/afsbio.com\/products\/bestrophin-1-rabbit-pab-es20817","provider":"AFSBio Inc.","version":"1.0","type":"link"}