{"product_id":"beta-arrestin-1-phospho-ser412-rabbit-polyclonal-antibody-bt-ap05811","title":"beta -Arrestin 1 (Phospho-Ser412) Rabbit Polyclonal Antibody - BT-AP05811","description":"\u003cp\u003ebeta -Arrestin 1 (Phospho-Ser412) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP05811-20, BT-AP05811-50, BT-AP05811-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Members of arrestin\/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones| neurotransmitters| or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system| it is expressed at high levels in peripheral blood leukocytes| and thus the BARK\/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Signal transduction; Neuroscience\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: ARRB1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: beta -Arrestin 1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P49407; Mouse: Q8BWG8; Rat: P29066\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: β-Arrestin 1;Ser412; Beta-arrestin-1; Arrestin beta-1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 408; Mouse: 109689; Rat: 25387\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239032971443,"sku":"BT-AP05811-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239033004211,"sku":"BT-AP05811-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239033036979,"sku":"BT-AP05811-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_f98e68a8-9085-4bf6-979b-1029f10a7b8b.png?v=1769388183","url":"https:\/\/afsbio.com\/products\/beta-arrestin-1-phospho-ser412-rabbit-polyclonal-antibody-bt-ap05811","provider":"AFSBio Inc.","version":"1.0","type":"link"}