{"product_id":"beta-casein-polyclonal-antibody-bs65597","title":"Beta-casein Polyclonal Antibody-BS65597","description":"\u003cp\u003eBeta-casein Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS65597-50, BS65597-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P10598\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Mouse,Rat,\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB=1:500-2000 \u003cbr\u003e\nnot yet tested in other applications.\u003cbr\u003e\noptimal dilutions\/concentrations should be determined by the end user.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Milk proteins are crucial for the development of all newborn mammals and caseins constitute the major proteins in mammalian milk. b- and k-caseins are the only caseins present in human milk. The b-casein\/k-casein ratio is higher in colostrum than in transitional and mature milk and is related to a better digestibility of colostrum casein micelles by the neonate during the first days of life. Human b-casein-encoding gene (Bca) contains a highly phosphorylated site, which is responsible for the calcium-binding capacity of b-casein. A common set of transcription factors are required for the expression of b-casein. Multiple binding sites for Stat5, C\/EBPb (CCAAT\/enchancer-binding protein) and several half-sites for glucocorticoid receptor (GR) are identified in the distal human enhancer of the b-casein gene. b-casein gene transcription is regulated primarily by a composite response element (CoRE), which integrates signaling from the lactogenic hormones PRL, insulin and hydrocortisone in mammary epithelial cells. NFkB functions as a negative regulator of b-casein gene expression during pregnancy by interfering with Stat5 tyrosine phosphorylation\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: affinity purified by Protein A\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Beta-casein polyclonal Antibody detects endogenous levels of Beta-casein protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~25-29kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Anti-Beta-casein at 1\/1000 dilution\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Beta-casein; Casoparan; Antioxidant peptide; Casohypotensin; CASB; CASB_BOVIN; Casein beta; CSN 2; Csn2; CASB_BOVIN.\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: KLH conjugated synthetic peptide derived from mouse Beta-casein:171-231\/231\u003c\/p\u003e \n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":43029544370355,"sku":"BS65597-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":43029544403123,"sku":"BS65597-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_1e3e63d8-7447-45d8-8ac9-8ef387324c55.jpg?v=1707221463","url":"https:\/\/afsbio.com\/products\/beta-casein-polyclonal-antibody-bs65597","provider":"AFSBio Inc.","version":"1.0","type":"link"}