{"product_id":"beta-catenin-monoclonal-antibody-mb66970","title":"Beta-catenin Monoclonal Antibody - MB66970","description":"\u003cp\u003eBeta-catenin Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB66970-50, MB66970-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: β-catenin is a key downstream effector in the Wnt signaling pathway . It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis . CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β . GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41 . Mutations at these sites resμlt in the stabilization of β-catenin protein levels and have been found in many tumor cell lines .\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IF\/ICC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CTNNB, Catenin beta-1, Beta-catenin\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Beta-catenin. The exact sequence is proprietary.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB (1\/1000 - 1\/2000), IF\/ICC (1\/10 - 1\/50)\u003c\/p\u003e\n\n\u003cp\u003ePurification: This antibody is purified through a protein G column.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of Beta-catenin protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 92 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: Adherens Junction signaling, ESC Pluripotency and Differentiation Signaling Pathway, ErbB HER Signaling, Wntβ catenin signaling.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P35222\u003c\/p\u003e\n\n\u003cp\u003eProduct: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946426359987,"sku":"MB66970-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946426392755,"sku":"MB66970-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/beta-catenin-monoclonal-antibody-mb66970","provider":"AFSBio Inc.","version":"1.0","type":"link"}