{"product_id":"bincard-rabbit-pab-es7746","title":"BinCARD rabbit pAb - ES7746","description":"\u003cp\u003eBinCARD rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES7746-50, ES7746-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: function:Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner., PTM:Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Contains 1 CARD domain., subcellular location:Co-expression with BCL10 induced translocation from nucleus to cytosol., subunit:Associates with BCL10 by CARD-CARD interaction., tissue specificity:Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level). Expressed in thymus and brain.,\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: C9orf89; Bcl10-interacting CARD protein; BinCARD\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/40000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human C9orf89. AA range:21-70\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 84270\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q96LW7\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: [Isoform 1]: Nucleus. Coexpression with BCL10 induced translocation from nucleus to cytosol.; [Isoform 2]: Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45201940971699,"sku":"ES7746-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45201941004467,"sku":"ES7746-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_c31fcc0e-a211-4ac3-bfff-076dedf9530b.png?v=1767118479","url":"https:\/\/afsbio.com\/products\/bincard-rabbit-pab-es7746","provider":"AFSBio Inc.","version":"1.0","type":"link"}