{"product_id":"biotin-rabbit-anti-mouse-cd5-monoclonal-antibody-a27413","title":"Biotin Rabbit anti-Mouse CD5 Monoclonal Antibody - A27413","description":"\u003cp\u003eBiotin Rabbit anti-Mouse CD5 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 2 x 100T, 5 x 100T\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A27413-200, A27413-500\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: CD5 is a type I transmembrane protein belonging to the scavenger receptor cysteine-enriched (SRCR) family, characterized by the presence of at least one SRCR domain containing 90-110 amino acids. CD5 is expressed in all mature T cells, B-1A subsets of mature B cells, and certain leukemia B cells. It is elevated in regulatory T and B cells (Tregs\/Bregs). CD5 expression was also elevated in incompetent T and B cells. Elevated levels of CD5 have also been found in many autoimmune diseases. CD5 binds to T cell receptors (TCR) and negatively regulates T cell activation and differentiation. The expression of CD5 in tumor-infiltrating T lymphocytes was negatively correlated with their antitumor activity. Recently, it has been reported that CD5 binds directly to IL6 and mediates downstream signal transduction. CD5+ B cells promote tumor growth in animal models. Agents targeting CD5 are being actively explored as therapeutic interventions for cancer and other conditions.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Monoclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplication: FC\u003c\/p\u003e\n\n\u003cp\u003eCross Reactivity: Mouse\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 54kDa Immunogen: Recombinant protein (or fragment).\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 12507\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P13379\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Ly-1; Ly-A; Ly-12; Lyt-1\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at 2-8℃. Avoid freeze.|Buffer: PBS with 0.09% Sodium azide,0.2% BSA,pH7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilution: FC,5 μl per 10^6 cells in 100 μl volume\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Immunology;Adaptive Immunity;B Cells;CD;Immunology;Adaptive Immunity;T Cells;CD;Stem Cells;Hematopoietic Progenitors;Lymphoid;B Lymphocytic Lineage;;Hematopoietic Progenitors;Lymphoid;T Lymphocytic Lineage\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: Cd5\u003c\/p\u003e\n\n\u003cp\u003eModifications: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Biotin\u003c\/p\u003e\n\n\u003cp\u003eClone Number Info: ARC61614\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"2 x 100T","offer_id":45189347934387,"sku":"A27413-200","price":67.2,"currency_code":"CAD","in_stock":true},{"title":"5 x 100T","offer_id":45189347967155,"sku":"A27413-500","price":109.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_b03c727f-4fe4-497d-9346-ac6c85c203be.png?v=1766421872","url":"https:\/\/afsbio.com\/products\/biotin-rabbit-anti-mouse-cd5-monoclonal-antibody-a27413","provider":"AFSBio Inc.","version":"1.0","type":"link"}