{"product_id":"blm-rabbit-polyclonal-antibody-es7150","title":"BLM Rabbit Polyclonal Antibody - ES7150","description":"\u003cp\u003eBLM Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES7150-50, ES7150-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs and may disable the 3'-5' helicase activity. The normal protein may act to suppress inappropriate recombination. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse,\u003c\/p\u003e \n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: BLM, RECQ2, RECQL3, Bloom syndrome protein, DNA helicase, RecQ-like type 2, RecQ2, RecQ protein-like 3\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human Bloom Syndrome. AA range:65-114\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: BLM\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: BLM Polyclonal Antibody detects endogenous levels of BLM protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Immunohistochemistry: 1\/100 - 1\/300. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/5000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: B-cell, Epithelium, Testis,\u003c\/p\u003e \n\n\u003cp\u003eMolecular Weight (Da): 159kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Homologous recombination, Fanconi anemia pathway\u003c\/p\u003e\n\n\u003cp\u003eFunction: Disease: Defects in BLM are the cause of Bloom syndrome (BLM) [MIM: 210900]. BLM is an autosomal recessive disorder characterized by proportionate pre- and postnatal growth deficiency, sun-sensitive telangiectatic hypo- and hyperpigmented skin, predisposition to malignancy, and chromosomal instability\u003cbr\u003e\nFunction: Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction\u003cbr\u003e\nOnline Information: BLM mutation db,PTM: Phosphorylated in response to DNA damage. Phosphorylation requires the FANCA-FANCC-FANCE-FANCF-FANCG protein complex, as well as the presence of RMI1\u003cbr\u003e\nSimilarity: Belongs to the helicase family. RecQ subfamily\u003cbr\u003e\nSimilarity: Contains 1 helicase ATP-binding domain\u003cbr\u003e\nSimilarity: Contains 1 helicase C-terminal domain\u003cbr\u003e\nSimilarity: Contains 1 HRDC domain\u003cbr\u003e\nSubunit: Part of the BRCA1-\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus Together with SPIDR, is redistributed in discrete nuclear DNA damage-induced foci following hydroxyurea (HU) or camptothecin (CPT) treatment Accumulated at sites of DNA damage in a RMI complex- and SPIDR-dependent manner\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: BLM\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Bloom syndrome protein\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: O88700\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46313694134451,"sku":"ES7150-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46313694167219,"sku":"ES7150-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/blm-rabbit-polyclonal-antibody-es7150","provider":"AFSBio Inc.","version":"1.0","type":"link"}