{"product_id":"bmi-1-rabbit-polyclonal-antibody-f270-bt-ap14458","title":"Bmi-1 Rabbit Polyclonal Antibody (F270) - BT-AP14458","description":"\u003cp\u003eBmi-1 Rabbit Polyclonal Antibody (F270)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP14458-20, BT-AP14458-50, BT-AP14458-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cancer; Cell biology; Epigenetics and nuclear signaling; Stem cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: BMI1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Bmi-1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P35226\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Bmi-1; Polycomb complex protein BMI-1; Polycomb group RING finger protein 4; RING finger protein 51\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 100532731\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239066820787,"sku":"BT-AP14458-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239066853555,"sku":"BT-AP14458-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239066886323,"sku":"BT-AP14458-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_5d4dc6e7-1101-455b-afb3-8894681ff7be.png?v=1769388663","url":"https:\/\/afsbio.com\/products\/bmi-1-rabbit-polyclonal-antibody-f270-bt-ap14458","provider":"AFSBio Inc.","version":"1.0","type":"link"}