{"product_id":"bmi-1-rabbit-polyclonal-antibody-f270-ra22427","title":"Bmi-1 Rabbit Polyclonal Antibody (F270) - RA22427","description":"\u003cp\u003eBmi-1 Rabbit Polyclonal Antibody (F270)\u003c\/p\u003e \n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA22427-50, RA22427-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: BMI1 proto-oncogene, polycomb ring finger (BMI1) Homo sapiens This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1) . This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015],\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: WB 1:500-2000\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)\u003c\/p\u003e \n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 100532731\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 37-43\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P35226\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121110868147,"sku":"RA22427-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121110900915,"sku":"RA22427-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_117fe584-2c86-4c7c-be7c-2ca1ea09936d.png?v=1773371236","url":"https:\/\/afsbio.com\/products\/bmi-1-rabbit-polyclonal-antibody-f270-ra22427","provider":"AFSBio Inc.","version":"1.0","type":"link"}