{"product_id":"bmi1-monoclonal-antibody-bt-mca2235","title":"BMI1 Monoclonal Antibody - BT-MCA2235","description":"\u003cp\u003eBMI1 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2235-50, BT-MCA2235-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2\/RING2.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and nuclear signaling, Cancer, Cell biology, Stem cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: BMI1\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC, ICC, FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 3E3\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: BMI1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human BMI1 expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 37kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P35226\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: PCGF4, RNF51, MGC12685, FLVI2\/BMI1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 648\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238594076851,"sku":"BT-MCA2235-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238594109619,"sku":"BT-MCA2235-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_02cdbdb7-bcf3-4fac-8e48-f53f5d0d8be3.png?v=1769382890","url":"https:\/\/afsbio.com\/products\/bmi1-monoclonal-antibody-bt-mca2235","provider":"AFSBio Inc.","version":"1.0","type":"link"}