{"product_id":"bmp-6-polyclonal-antibody-bt-ap00928","title":"BMP-6 Polyclonal Antibody - BT-AP00928","description":"\u003cp\u003eBMP-6 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP00928-20, BT-AP00928-50, BT-AP00928-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: BMP6 (bone morphogenetic protein 6) encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of BMP6 may be associated with progression of breast and prostate cancer. Mutations in BMP6 may be associated with iron overload in human patients.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: BMP6\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: BMP-6 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 57226\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P22004; Mouse: P20722\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: BMP6; VGR; Bone morphogenetic protein 6; BMP-6; VG-1-related protein; VG-1-R; VGR-1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 654\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240139907251,"sku":"BT-AP00928-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240139940019,"sku":"BT-AP00928-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240139972787,"sku":"BT-AP00928-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_12298ea7-73b0-4d69-8d71-5cd67e9ae250.png?v=1769404057","url":"https:\/\/afsbio.com\/products\/bmp-6-polyclonal-antibody-bt-ap00928","provider":"AFSBio Inc.","version":"1.0","type":"link"}