{"product_id":"bmp-8a-rabbit-polyclonal-antibody-es1780","title":"BMP-8A Rabbit Polyclonal Antibody - ES1780","description":"\u003cp\u003eBMP-8A Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES1780-50, ES1780-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in development of the reproductive system. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse,\u003c\/p\u003e \n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: BMP8A, Bone morphogenetic protein 8A, BMP-8A\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human BMP8A. AA range:253-302\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: BMP-8A\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: BMP-8A Polyclonal Antibody detects endogenous levels of BMP-8A protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Brain, Hippocampus, Thyroid gland,\u003c\/p\u003e \n\n\u003cp\u003eObserved Band (KD): 45-55kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, Thermogenesis\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis\u003cbr\u003e\nOnline Information: Bone morphogenetic protein 8A entry,Similarity: Belongs to the TGF-beta family\u003cbr\u003e\nSubunit: Homodimer, disulfide-linked\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Secreted\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: BMP8A\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Bone morphogenetic protein 8A\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: P34821\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315665555635,"sku":"ES1780-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315665588403,"sku":"ES1780-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/bmp-8a-rabbit-polyclonal-antibody-es1780","provider":"AFSBio Inc.","version":"1.0","type":"link"}