{"product_id":"bob-1-polyclonal-antibody-ra22464","title":"Bob 1 Polyclonal Antibody - RA22464","description":"\u003cp\u003eBob 1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA22464-50, RA22464-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: disease:A chromosomal aberration involving POU2AF1\/OBF1 may be a cause of a form of B-cell leukemia. Translocation t (3;11) (q27;q23) with BCL6.,function:Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.,PTM:Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the POU2AF1 family.,tissue specificity:B-cell specific.,\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: IHC-p 1:50-200, ELISA 1:10000-20000\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1;BOB-1;OCA-B;OCT-binding factor 1)\u003c\/p\u003e \n\n\u003cp\u003eApplications: IHC-p; IF (paraffin section) ; ELISA\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Rat; Mouse\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 5450\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q16633\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45119727304883,"sku":"RA22464-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45119727337651,"sku":"RA22464-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_99a8797e-dee3-4288-9f6a-8f276ea647b7.png?v=1773356334","url":"https:\/\/afsbio.com\/products\/bob-1-polyclonal-antibody-ra22464","provider":"AFSBio Inc.","version":"1.0","type":"link"}