{"product_id":"boct-polyclonal-antibody-bt-ap00953","title":"BOCT Polyclonal Antibody - BT-AP00953","description":"\u003cp\u003eBOCT Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP00953-20, BT-AP00953-50, BT-AP00953-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Metabolism\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: SLC22A17\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: BOCT Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 57686\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q8WUG5; Mouse: Q9D9E0; Rat: Q9P290\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: SLC22A17; BOCT; BOIT; Solute carrier family 22 member 17; 24p3 receptor; 24p3R; Brain-type organic cation transporter; Lipocalin-2 receptor; Neutrophil gelatinase-associated lipocalin receptor; NgalR\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 51310; Mouse: 59049; Rat: 305886\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240141283507,"sku":"BT-AP00953-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240141316275,"sku":"BT-AP00953-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240141349043,"sku":"BT-AP00953-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_b73f36b2-005c-46c0-99e8-dfc41f897a76.png?v=1769404079","url":"https:\/\/afsbio.com\/products\/boct-polyclonal-antibody-bt-ap00953","provider":"AFSBio Inc.","version":"1.0","type":"link"}