{"product_id":"braf-monoclonal-antibody-bt-mca4697","title":"BRAF Monoclonal Antibody - BT-MCA4697","description":"\u003cp\u003eBRAF Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA4697-50, BT-MCA4697-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a protein belonging to the RAF family of serine\/threonine protein kinases. This protein plays a role in regulating the MAP kinase\/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: BRAF\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, FCM\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 2A10D7\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: BRAF\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human BRAF (AA: 299-447) expressed in HEK293-6e.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 84.4kda\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P15056\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: NS7, B-raf, BRAF1, RAFB1, B-RAF1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 673\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238387867827,"sku":"BT-MCA4697-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238387900595,"sku":"BT-MCA4697-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_c89e9180-9841-46a3-98cc-12161afdc27c.png?v=1769379737","url":"https:\/\/afsbio.com\/products\/braf-monoclonal-antibody-bt-mca4697","provider":"AFSBio Inc.","version":"1.0","type":"link"}