{"product_id":"brca1-phospho-ser1423-rabbit-pab-es7267","title":"BRCA1 (phospho Ser1423) rabbit pAb - ES7267","description":"\u003cp\u003eBRCA1 (phospho Ser1423) rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES7267-50, ES7267-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript varian\u003c\/p\u003e\n\n\u003cp\u003eAlternate Name: BRCA1; RNF53; Breast cancer type 1 susceptibility protein; RING finger protein 53\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/5000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human BRCA1 around the phosphorylation site of Ser1423. AA range:1391-1440\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 210kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 672\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P38398\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus. Chromosome. Cytoplasm. Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by ABRAXAS1 and the BRCA1-A complex (PubMed:26778126). Translocated to the cytoplasm during UV-induced apoptosis (PubMed:20160719).; [Isoform 3]: Cytoplasm.; [Isoform 5]: Cytoplasm.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202335039667,"sku":"ES7267-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202335072435,"sku":"ES7267-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_10e5ad5f-fef6-4b08-b153-40384f9910ff.png?v=1767126856","url":"https:\/\/afsbio.com\/products\/brca1-phospho-ser1423-rabbit-pab-es7267","provider":"AFSBio Inc.","version":"1.0","type":"link"}