{"product_id":"brca2-polyclonal-antibody-ra22481","title":"BRCA2 Polyclonal Antibody - RA22481","description":"\u003cp\u003eBRCA2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA22481-50, RA22481-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: BRCA2, DNA repair associated (BRCA2) Homo sapiens Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008],\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: BRCA2; FACD; FANCD1; Breast cancer type 2 susceptibility protein; Fanconi anemia group D1 protein\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC-p; IF (paraffin section) ; ELISA\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Rat\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 675\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P51587\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45119727960243,"sku":"RA22481-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45119727993011,"sku":"RA22481-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_ecf29b3d-4e95-4c9f-9969-cfe29a8d4fc6.png?v=1773356338","url":"https:\/\/afsbio.com\/products\/brca2-polyclonal-antibody-ra22481","provider":"AFSBio Inc.","version":"1.0","type":"link"}