{"product_id":"btr1-rabbit-polyclonal-antibody-es1799","title":"BTR1 Rabbit Polyclonal Antibody - ES1799","description":"\u003cp\u003eBTR1 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES1799-50, ES1799-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a voltage-regulated, electrogenic sodium-coupled borate cotransporter that is essential for borate homeostasis, cell growth and cell proliferation. Mutations in this gene have been associated with a number of endothelial corneal dystrophies including recessive corneal endothelial dystrophy 2, corneal dystrophy and perceptive deafness, and Fuchs endothelial corneal dystrophy. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse,\u003c\/p\u003e \n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: SLC4A11, BTR1, Sodium bicarbonate transporter-like protein 11, Bicarbonate transporter-related protein 1, Sodium borate cotransporter 1, NaBC1, Solute carrier family 4 member 11\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human SLC4A11. AA range:291-340\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: BTR1\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: BTR1 Polyclonal Antibody detects endogenous levels of BTR1 protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Widely expressed, Highly expressed in kidney, testis, salivary gland, thyroid, trachea and corneal endothelium, Not detected in retina and lymphocytes,, [Isoform 3]: Expressed in corneal endothelium (at protein level),, [Isoform 5]: The predominant isoform in corneal endothelium (at protein level),\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 100kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Disease: Defects in SLC4A11 are the cause of corneal dystrophy and perceptive deafness (CDPD) [MIM: 217400], also known as corneal dystrophy and sensorineural deafness or Harboyan syndrome. CDPD consists of congenital corneal endothelial dystrophy and progressive perceptive deafness. Inheritance is autosomal recessive\u003cbr\u003e\nDisease: Defects in SLC4A11 are the cause of corneal endothelial dystrophy type 2 (CHED2) [MIM: 217700], also known as congenital hereditary endothelial dystrophy of cornea. This bilateral corneal dystrophy is characterized by corneal opacification and nystagmus. Inheritance is autosomal recessive\u003cbr\u003e\nFunction: Transporter involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter\u003cbr\u003e\nPTM: Glycosylated\u003cbr\u003e\nSimilarity: Belongs to the anion exchanger (TC\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cell membrane, Multi-pass membrane protein Basolateral cell membrane, Multi-pass membrane protein\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: SLC4A11\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Sodium bicarbonate transporter-like protein 11\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: A2AJN7\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315740594355,"sku":"ES1799-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315740627123,"sku":"ES1799-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/btr1-rabbit-polyclonal-antibody-es1799","provider":"AFSBio Inc.","version":"1.0","type":"link"}