{"product_id":"cμl2-i726-polyclonal-antibody-bs1082","title":"Cμl2 (I726) Polyclonal Antibody - BS1082","description":"\u003cp\u003eCμl2 (I726) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS1082-50, BS1082-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cμllin proteins comprise a distinct family of mediators that participate in the selective targeting of proteins for ubiquitin (Ub)-mediated proteolysis. Cμl-1, which is the mammalian homolog of Cdc53 from yeast, is an integral component of the E3 ubiquitin ligase complex designated SCF. The SCF(Skp1\/Cμl-1\/F-box protein complex) consists of Skp1 associating with both Cμl-1 and an F-box protein, such as Skp2, which determines the substrate specificity of the complex. Cμl-1 mediated ubiquitination resμlts in the degradation of cell cycle proteins cyclin D, p21 and cyclin E. Another cμllin, Cμl-3 facilitates the degradation of cyclin E independent of SCF activity, while Cμl-2 associates with the tumor suppressing protein VHL and elongin B to form VBC complexes, which structurally resemble the SCF ligase. Proteolysis also occurs by way of Cμl-4 associating with Nedd-8, a ubiquitin- like protein, where it too functions as an active component of a mμltifunctional E3 complex. Cμl-5, or vasopressin-activated, calcium-mobilizing protein (VACM-1), is also included in the cμllin family as it shares substantial sequence homology with Cμl-1.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Cμllin 2, Cμllin2, Cμl2, Cμl 2, CμlLIN-2, MGC131970\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 696-742 of Human Cμl-2.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB: 1:500~1:1000\u003cbr\u003e\nIHC: 1:50~1:200\u003cbr\u003e\nIF: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Cμllin 2 (I726) polyclonal antibody detects endogenous levels of Cμllin 2 protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 82, 84 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: Q13617\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45936730374323,"sku":"BS1082-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45936730407091,"sku":"BS1082-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image.jpg?v=1788296056","url":"https:\/\/afsbio.com\/products\/c%ce%bcl2-i726-polyclonal-antibody-bs1082","provider":"AFSBio Inc.","version":"1.0","type":"link"}