{"product_id":"c-abl-phospho-tyr89-rabbit-polyclonal-antibody-bt-ap06659","title":"c-Abl (Phospho-Tyr89) Rabbit Polyclonal Antibody - BT-AP06659","description":"\u003cp\u003ec-Abl (Phospho-Tyr89) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP06659-20, BT-AP06659-50, BT-AP06659-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes| including cell division| adhesion| differentiation| and response to stress. The activity of the protein is negatively regulated by its SH3 domain| whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation| suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias| most notably the t(9;22) translocation that results in a fusion with the 5andapos; end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants| which contain alternative first exons that are spliced to the remaining common exons.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cancer; Epigenetics and nuclear signaling; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: ABL1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: c-Abl\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P00519; Mouse: P00520\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: c-Abl;Tyr89; Tyrosine-protein kinase ABL1; EC 2.7.10.2; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 25; Mouse: 11350\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45238973071539,"sku":"BT-AP06659-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45238973104307,"sku":"BT-AP06659-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238973137075,"sku":"BT-AP06659-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_c087f130-7840-49d7-b327-2dc5431feefc.png?v=1769387406","url":"https:\/\/afsbio.com\/products\/c-abl-phospho-tyr89-rabbit-polyclonal-antibody-bt-ap06659","provider":"AFSBio Inc.","version":"1.0","type":"link"}