{"product_id":"c-ebp-β-v259-polyclonal-antibody-bs1942","title":"C\/EBP-β (V259) Polyclonal Antibody-BS1942","description":"\u003cp\u003eC\/EBP-β (V259) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers:BS1942-50, BS1942-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P17676\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: IHC: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: C\/EBP β is a member of the C\/EBP transcription factor family. The C\/EBP β gene encodes several isoforms, which have truncated transcription activation domains by the alternative translational initiation at multipe AUG start sites. Initiation of translation at the in-frame AUGs forms four C\/EBP β isoforms. C\/EBP β is also known as interleukin 6-dependent DNA-binding protein (IL6DBP), liver activator protein(LAP) or liver-enriched transcriptional activator protein transcription factor 5 (TCF5). C\/EBP β contributes to the regulation of the acute phase response in hepatocytes. Stat3 has an important function in IL-6-mediated transcription of the C\/EBP β gene that has direct implication for acute phase response in liver cells.The 35 kDa C\/EBP β form requires phosphorylation for its DNA binding ability, and increased binding of C\/EBP β isoforms during acute-phase reaction occurs through its upregulation and structural modification.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 19, 36, 38 kDa\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: C\/EBP-β (V259) polyclonal antibody detects endogenous levels of total C\/EBP-β protein.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003cbr\u003e\nAlternative Name: CCAAT\/enhancer-binding protein beta; C\/EBP β; C\/EBPβ; C\/EBP beta; Liver activator protein; LAP; Liver-enriched inhibitory protein; LIP; Nuclear factor NF-IL6; Transcription factor 5; TCF-5; CEBPB; TCF5; ORF Names: PP9092\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 220-270 of Human C\/EBP-β.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42895062433971,"sku":"BS1942-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42895062466739,"sku":"BS1942-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_b1bca360-eca1-497f-9fc3-b67896284e9b.jpg?v=1702573172","url":"https:\/\/afsbio.com\/products\/c-ebp-%ce%b2-v259-polyclonal-antibody-bs1942","provider":"AFSBio Inc.","version":"1.0","type":"link"}