{"product_id":"c-myc-phospho-t58-s62-polyclonal-antibody-bs94080","title":"c-Myc (Phospho-T58\/S62) Polyclonal Antibody-BS94080","description":"\u003cp\u003ec-Myc (Phospho-T58\/S62) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS94080-50, BS94080-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P01106(Human) P09416(Rat)\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB ICC\/IF IP\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:1,000\u003cbr\u003e\nICC:1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Myc proteins are nuclear proteins with relatively short half lives. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastomas. The L-Myc gene has been reported to be amplified and expressed at high level in human small cell lung carcinomas. The presence of three sequence motifs in the c-Myc COOH terminus, including the leucine zipper, the helix-loop-helix and a basic region provided initial evidence for a sequence-specific binding function. A basic region helix-loop-helix leucine zipper motif (bHLH-Zip) protein, designated Max, specifically associates with c-Myc, N-Myc and L-Myc proteins. The Myc-Max complex binds to DNA in a sequence-specific manner under conditions where neither Max nor Myc exhibit appreciable binding. Max can also form heterodimers with at least two additional bHLH-Zip proteins, Mad and Mxi1, and Mad-Max dimers have been shown to repress transcription through interaction with mSin3.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: ProA affinity purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of Phospho-c-Myc (T58+S62) on K562 cellsLysates using anti-Phospho-c-Myc (T58+S62) antibody at 1\/1,000 dilution.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 49 kDa\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: c-Myc (Phospho-T58\/S62) polyclonal antibody detects endogenous levels of c-Myc protein only when phosphorylated at T58\/S62.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: bHLHe39, MYC, Avian myelocytomatosis viral oncogene homolog, bHLHe39, c Myc, Class E basic helix-loop-helix protein 39, MRTL, Myc, Myc protein, Myc proto oncogene protein, Myc proto-oncogene protein, myc related translation\/localization regulatory factor, MYC, Myc2, MYCC, Niard, Nird, Proto-oncogene c-Myc, Transcription factor p64, v myc avian myelocytomatosis viral oncogene homolog, v myc myelocytomatosis viral oncogene homolog,\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Synthetic phospho-peptide corresponding to residues surrounding Thr58 and Ser62 of human c-Myc.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Phosphorylation\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42939210268851,"sku":"BS94080-50","price":415.38,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42939210301619,"sku":"BS94080-100","price":640.78,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_179c1e12-a184-4ef9-8fbe-ebc49eb528fe.jpg?v=1704545134","url":"https:\/\/afsbio.com\/products\/c-myc-phospho-t58-s62-polyclonal-antibody-bs94080","provider":"AFSBio Inc.","version":"1.0","type":"link"}