{"product_id":"c-myc-phospho-thr358-polyclonal-antibody-ra23576","title":"c-Myc (phospho Thr358) Polyclonal Antibody - RA23576","description":"c-Myc (phospho Thr358) Polyclonal Antibody\n\nSizes: 50μL, 100μL\n\nCatalogue Numbers: RA23576-50, RA23576-100\n\nCitations, Manuals and MSDS Available upon request.\n\nBackground: v-myc avian myelocytomatosis viral oncogene homolog (MYC) Homo sapiens The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008],\n\nCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\n\nStorage Instructions: -20°C\/1 year\n\nRecommended dilutions: Immunohistochemistry: 1\/100 - 1\/300. Immunoprecipitation: 2-5 ug\/mg lysate. ELISA: 1\/20000. Not yet tested in other applications.\n\nAlternative Names: MYC; BHLHE39; Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64\n\nApplications: IHC-p; IF (paraffin section) ; IP; ELISA\n\nSpecies Cross-Reactivity: Human; Mouse; Rat\n\nGeneID (Human): 4609\n\nProtein MW (KDa): 50, (also ~60KD in some samples) \n\nSWISS: P01106\n\nSource: Rabbit\n\nResearch Use Only","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121211596979,"sku":"RA23576-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121211629747,"sku":"RA23576-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_e688be47-8768-4261-9a39-b81e444b7115.png?v=1773345276","url":"https:\/\/afsbio.com\/products\/c-myc-phospho-thr358-polyclonal-antibody-ra23576","provider":"AFSBio Inc.","version":"1.0","type":"link"}