{"product_id":"c-myc-phospho-thr358-rabbit-pab-es6306","title":"c-Myc (phospho Thr358) rabbit pAb - ES6306","description":"\u003cp\u003ec-Myc (phospho Thr358) rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES6306-50, ES6306-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: MYC; BHLHE39; Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC; IF; IP; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Immunohistochemistry: 1\/100 - 1\/300. Immunoprecipitation: 2-5 ug\/mg lysate. ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human Myc around the phosphorylation site of Thr358. AA range:325-374\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 50, (also ~60KD in some samples)\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 4609\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P01106\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus, nucleoplasm. Nucleus, nucleolus.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202291785907,"sku":"ES6306-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202291818675,"sku":"ES6306-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_e38b174e-038b-4e01-8224-b72e7ede0b99.png?v=1767125889","url":"https:\/\/afsbio.com\/products\/c-myc-phospho-thr358-rabbit-pab-es6306","provider":"AFSBio Inc.","version":"1.0","type":"link"}